Title of article :
Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production
Author/Authors :
Hiroshi Miyazaki، نويسنده , , Tsuyoshi Ogiku، نويسنده , , Hiroshi Sai، نويسنده , , Hiroshi Ohmizu، نويسنده , , Jun Murakami، نويسنده , , Akio Ohtani، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A novel series of butadiene-imide 1 (T-686) derivatives having an inhibitory activity against PAI-1 production was synthesized and evaluated their biological activities and DMPK profiles, in which 15k (T-2639) was selected as the best compound based on its strong antithrombotic activity and good bioavailability.
Keywords :
Plasminogen activator inhibitor-1 (PAI-1) , Inhibitor of PAI-1 production , T-2639
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
