Title of article :
Calmodulin inhibitory activity of the malbrancheamides and various analogs
Author/Authors :
Kenneth A. Miller، نويسنده , , Mario Figueroa، نويسنده , , Meriah W.N. Valente، نويسنده , , Thomas J. Greshock، نويسنده , , Rachel Mata، نويسنده , , Robert M. Williams، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.image
Keywords :
Calmodulin inhibition , Prenylated indole alkaloid , Malbrancheamide
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
