Title of article
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore
Author/Authors
James McNulty، نويسنده , , Justin Mao، نويسنده , , Romelo Gibe، نويسنده , , Ruowei Mo، نويسنده , , Sonja Wolf، نويسنده , , George R. Pettit، نويسنده , , Delbert L. Herald، نويسنده , , Michael R. Boyd، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
169
To page
172
Abstract
Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800301
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