Title of article
Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC
Author/Authors
Alex J. Zhang، نويسنده , , Sangeeta Khare، نويسنده , , Kuppan Gokulan، نويسنده , , D. Scott Linthicum، نويسنده , , Kevin Burgess، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
207
To page
210
Abstract
Twelve dimeric peptidomimetics 1 were prepared via a divergent–convergent strategy. These peptidomimetics incorporated the same amino acids as i+1 and i+2 residues in key β-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800310
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