Author/Authors :
Xiaobin Ding، نويسنده , , Matthew D. Vera، نويسنده , , Bo Liang، نويسنده , , Yuming Zhao، نويسنده , , Michael S. Leonard، نويسنده , , Madeleine M. Joullié، نويسنده ,
Abstract :
The synthesis and antitumor activity of a novel didemnin B analogue containing a Ψ[CH2NH] amide bond surrogate between N-Me- -Leu7 and Pro8 are reported. The analogue shows activity (GI50=4 nM) comparable to that of didemnin B (GI50=13 nM) in the NCI-60 tumor cell screen. This result, along with new data from previously reported synthetic didemnin analogues, is discussed within the context of the side-chain SAR for didemnins.
