Author/Authors :
Zhili Li، نويسنده , , Michael W. Fennie، نويسنده , , Bruce Ganem، نويسنده , , Matthew T. Hancock، نويسنده , , Muris Koba lija، نويسنده , , Donna Rattendi، نويسنده , , Cyrus J. Bacchi، نويسنده , , Mary C. OʹSullivan، نويسنده ,
Abstract :
Several N-(3-phenylpropyl)-substituted spermidine and spermine derivatives were prepared and found to be potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase (seven compounds with Ki values <5 μM are described). The most effective inhibitor studied was compound 12 with a Ki value of 0.151 μM. Six of the compounds described are also effective trypanocides with IC50 values <1 μM.
