Title of article
Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors
Author/Authors
Benoit Bachand، نويسنده , , Micheline Tarazi، نويسنده , , Yves St-Denis، نويسنده , , Jeremy J. Edmunds، نويسنده , , Peter D. Winocour، نويسنده , , Lorraine Leblond، نويسنده , , M. Arshad Siddiqui، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
287
To page
290
Abstract
Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800329
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