Author/Authors :
John E. Macor، نويسنده , , David Gurley، نويسنده , , Thomas Lanthorn، نويسنده , , James Loch، نويسنده , , Robert A. Mack، نويسنده , , George Mullen، نويسنده , , Oahn Tran، نويسنده , , Nicole Wright، نويسنده , , John C. Gordon، نويسنده ,
Abstract :
The 5-HT3 receptor antagonist tropisetron (ICS 205-930) was found to be a potent and selective partial agonist at α7 nicotinic receptors. Two other 5-HT3 receptor antagonists, ondansetron and LY-278,584, were found to lack high affinity at the α7 nicotinic receptor. Quinuclidine analogues (1 and 2) of tropisetron were also found to be potent and selective partial agonists at α7 nicotinic receptors.
