Author/Authors :
Xinrong Tian، نويسنده , , Ling-Wei Hsin، نويسنده , , Elizabeth L. Webster، نويسنده , , Carlo Contoreggi، نويسنده , , George P. Chrousos، نويسنده , , Philip W. Gold، نويسنده , , Kamal Habib، نويسنده , , Alejandro Ayala، نويسنده , , William C. Eckelman، نويسنده , , Arthur E. Jacobson، نويسنده , , Kenner C. Rice، نويسنده ,
Abstract :
A high-affinity radioligand for CRHR1 has been prepared that can serve as a template for the development of SPECT imaging agents. The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylpyrimidine-4,6-diamine (6b, Ki=14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki=21 nM), were synthesized in four steps from compound 3.
