Title of article :
Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors
Author/Authors :
Pauline C. Ting، نويسنده , , Joe F. Lee، نويسنده , , John C. Anthes، نويسنده , , Neng-Yang Shih، نويسنده , , John J. Piwinski، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
