Title of article
Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors
Author/Authors
Ghilsoo Nam، نويسنده , , Cheol Min Yoon، نويسنده , , Euikyung Kim، نويسنده , , Chung K. Rhee، نويسنده , , Joong Hyup Kim، نويسنده , , Jung-Hyu Shin، نويسنده , , Sung Hoon Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
611
To page
614
Abstract
The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 5l and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800406
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