Effects of the Transdermal Nicotine Patch on Normalization of HDL-C and Its Subfractions

Background. Smoking reduces HDL-C and its subfractions, and smoking cessation leads to normalization of these lipoproteins. Nicotine replacement therapy is an important weapon employed by those attempting to quit smoking. This study examined the effects of the transdermal nicotine patch (“patch”) on lipoproteins. Methods. Ten male and 17 female smokers refrained from smoking for 77 days. The patch was utilized during the first 35 days and then removed for the remaining 42 days. Seven male and 9 female nonsmokers were controls. Results. HDL-C, HDL2-C, and HDL3-C levels were significantly lower in smokers when compared with controls. These differences were sustained during the initial 35 days when using the patch. Over the following 42 days, however, these lipoproteins normalized to values similar to those of control subjects. Females who quit smoking gained 2.1 kg after the patch was removed. Conclusions. It was concluded that nicotine as administered by the transdermal nicotine patch inhibits normalization of HDL-C, HDL2-C, and HDL3-C in those who have quit smoking. Removal of the patch results in normalization of these lipoproteins. The patch appeared to prevent weight gain among female subjects.