Quantitation of Doppler color flow jet areas for mitral regurgitation in children: angiographic correlation

Eighteen patients with chronic isolated rheumatic mitral regurgitation aged between 7 and 19 years (mean age±SD, 12.69±3.47 years) were analyzed with color Doppler imaging. Sixteen patients were performed cardiac catheterization within 24 h. Jets were classified as eccentric and central. Regurgitant jet area and its ratio to left atrial area and body surface area were measured by Doppler color flow imaging. Regurgitant volume and regurgitant fractions were calculated with angiography. There was a good correlation between regurgitant jet area and angiographic grade of mitral regurgitation (P<0.01). The correlation between regurgitant jet area/left atrial area ratios and angiographic grade of mitral regurgitation was limited (P<0.01). There was excellent correlation between regurgitant jet area/body surface area and angiographic regurgitant fraction (r=0.85; P<0.001). There was also a good correlation between regurgitant jet area and regurgitant fraction (r=0.82; P<0.001). However, the relation of regurgitant jet area/left atrial area to regurgitant fraction was weak (r=0.72; P<0.01). In conclusion, the measurement of regurgitant fraction and its ratios to left atrial area and body surface area by color Doppler flow imaging can predict the angiographic severity in children who have even eccentric regurgitant jets.