The increase in P-wave dispersion is associated with the duration of disease in patients with Behçetʹs disease

Aim P-wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. Behçetʹs disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in Behçetʹs disease. The aim of this study was to evaluate myocardial involvement noninvasively in patients with BD by measuring PD. Methods Study population included 29 patients with BD (group I), (16 males, mean age: 60.4 ± 10.1 years), and 45 normal (group II), (23 males, mean age: 61.2 ± 12.0 years). The maximum and minimum P-wave duration (Pmax and Pmin) and PD were measured from the 12-lead surface electrocardiogram. Echocardiographic examination was also performed. Results There was no statistically significant difference between two groups in respect to age, gender, hypertension, diabetes mellitus, hyperlipidemia and cigarette smoking (p > 0.05). Pmax and PD of patients with BD were found to be significantly higher than those of control subjects (116.2 ± 14.0 ms vs. 102.0 ± 16.5 and 49.3 ± 12.7 ms vs. 29.3 ± 8.5 ms, respectively p < 0.0001). Moreover, we found a significant positive correlation between PD with BD duration (r = 0.78, p < 0.0001). Conclusion Pmax and PD are found to be greater in patients with BD than in controls and are related with the duration of the disease.