Title of article
Presenilin 1 is Actively Degraded by the 26S Proteasome
Author/Authors
P. E. Fraser، نويسنده , , Stéphane G. Lévesque، نويسنده , , G. Yu، نويسنده , , L. R. Mills، نويسنده , , J. Thirlwell، نويسنده , , M. Frantseva، نويسنده , , S. E. Gandy، نويسنده , , James M. Seeger، نويسنده , , P. L. Carlen، نويسنده , , P. St George-Hyslop، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
3
From page
19
To page
21
Abstract
The metabolic pathways governing the turnover of presenilin 1 (PS1) have been incompletely worked out. The PS1 holoprotein has low abundance in many cells and appears to undergo endoproteolytic cleavage near residue 298. We provide evidence that one mechanism by which the PS1 holoprotein is degraded is through the action of the 26S proteasome. We also show that the proteasome does not participate in the endoproteolytic cleavage.
Keywords
PS1 , pS2 , Proteasome , degradation , Transmembrane protein , Alzheimer Disease , presenilin , Proteolysis , Endoplasmic reticulum
Journal title
Neurobiology of Aging
Serial Year
1998
Journal title
Neurobiology of Aging
Record number
819712
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