Title of article :
Neuregulin-1 reduces ischemia-induced brain damage in rats
Author/Authors :
Woei-Cherng Shyu، نويسنده , , Shinn-Zong Lin، نويسنده , , Ming-Fu Chiang، نويسنده , , Hui-I Yang، نويسنده , , Peterus Thajeb، نويسنده , , Hung Li، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
10
From page :
935
To page :
944
Abstract :
Neuregulin-1 (NRG-1) is expressed throughout the immature and adult central nervous system and it has been demonstrated to influence the migration of a variety of cell types in developing brain. Elevated levels of NRG-1 transcript are found in the adult brain after injury, leading to the suggestion that NRG-1 is involved in the physiological response to neuronal injury. Here, we report our findings that rats pre-treated with NRG-1 protein, undergoing cerebral ischemia 30 min later, had increased motor performance and less cerebral infarction than untreated rats. In the cortex of NRG-1 treated rats, ischemia induced a decrease in caspase-3 immunoreactivity and a reduction in the density of cells positive for terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end-labeling. Improvement in behavioral assays was also found in animals treated with NRG-1. Pre-treatment with NRG-1 did not alter cerebral blood flow or other physiological parameters. NRG-1 reduced ischemia/reperfusion injury, indicating that it may act as an endogenous neuroprotective factor against stroke. Therefore, NRG-1 may represent a target for the development of new treatments for stroke.
Keywords :
rat , Neuregulin-1 , neuroprotection , Cerebral ischemia
Journal title :
Neurobiology of Aging
Serial Year :
2004
Journal title :
Neurobiology of Aging
Record number :
820477
Link To Document :
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