Author/Authors :
Chiara Fenoglio، نويسنده , , Daniela Galimberti، نويسنده , , Carlo Lovati، نويسنده , , Ilaria Guidi، نويسنده , , Alberto Gatti، نويسنده , , Sergio Fogliarino، نويسنده , , Marco Tiriticco، نويسنده , , Claudio Mariani، نويسنده , , Gianluigi Forloni، نويسنده , , Carla Pettenati، نويسنده , , Pierluigi Baron، نويسنده , , Giancarlo Conti، نويسنده , , Nereo Bresolin، نويسنده , , Elio scarpini، نويسنده ,
Abstract :
MCP-1 levels are increased in CSF of patients with Alzheimer’s disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position −2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed.
Keywords :
Alzheimer’s Disease , polymorphism , chemokines , Monocyte chemoattractant protein-1 , genetics , MCP-1
