Sex differences in age-related motor slowing in the rhesus monkey: behavioral and neuroimaging data

The nigrostriatal system is critical for fine motor function and its deterioration during aging is thought to underlie the decline in fine manual ability of old persons. Because estrogen has a neuroprotective effect on this system, one might expect womenʹs motor function to be less vulnerable to the detrimental effects of aging than that of men. We examined this hypothesis in the rhesus monkey, which has been established as an excellent model of human age-related motor impairment. We tested 28 young and old rhesus monkeys of both sexes in a task involving the retrieval of a Life Saver® candy from rods of different complexity to determine whether fine motor ability (1) is sexually dimorphic, (2) declines with age and (3) declines differently in males and females. In addition, we measured the whole brain volume, the volumes of the caudate, putamen, hippocampal formation and the area of the corpus callosum in a subset of the monkeys (n = 15) for which magnetic resonance images of the brain were available.