Author/Authors :
Ilaria Guidi، نويسنده , , Daniela Galimberti، نويسنده , , Eliana Venturelli، نويسنده , , Carlo Lovati، نويسنده , , Roberto Del Bo، نويسنده , , Chiara Fenoglio، نويسنده , , Alberto Gatti، نويسنده , , Roberto Dominici، نويسنده , , Sara Galbiati، نويسنده , , Roberta Virgilio، نويسنده , , Simone Pomati، نويسنده , , Giacomo P. Comi، نويسنده , , Claudio Mariani، نويسنده , , Gianluigi Forloni، نويسنده , , Nereo Bresolin، نويسنده , , Elio scarpini، نويسنده ,
Abstract :
The distribution of the Glu298Asp polymorphism in NOS3 gene was determined in 405 Italian patients with “probable” Alzheimerʹs disease (AD) compared with 253 age-matched controls. Total plasma homocysteine (tHcy) levels were evaluated in 97 patients and 23 controls, and were correlated with the Glu298Asp genotype. A significantly increased frequency of the Glu/Glu genotype in late onset AD (LOAD) patients was found. tHcy levels were significantly increased in patients compared with controls and, notably, higher in LOAD than in early onset AD (EOAD). Stratifying by the Glu298Asp genotype, a trend toward an increase of tHcy was present in Glu/Glu homozygous.
This wild type genotype seems to be associated with LOAD. tHcy levels are significantly increased in AD compared with controls and, moreover, higher in LOAD than in EOAD, possibly in correlation with the microvascular disease occurring with aging. Besides, a contribution of the Glu/Glu genotype in increasing tHcy levels has been observed.
Keywords :
Endothelial nitric oxide synthase (NOS3) , polymorphism , Total plasma homocysteine (tHcy) , Alzheimer’s Disease , Risk factor
