Author/Authors :
Katharina Buerger، نويسنده , , Markus Otto، نويسنده , , Stefan J. Teipel، نويسنده , , Raymond Zinkowski، نويسنده , , Kaj Blennow، نويسنده , , John DeBernardis، نويسنده , , Daniel Kerkman، نويسنده , , Johannes Schr?der، نويسنده , , Peter Sch?nknecht، نويسنده , , Lukas Cepek، نويسنده , , Cheryl McCulloch، نويسنده , , Hans-Jürgen M?ller، نويسنده , , Jens Wiltfang، نويسنده , , Hans Kretzschmar، نويسنده , , Harald Hampel، نويسنده ,
Abstract :
To study the potential diagnostic value of abnormally phosphorylated tau protein in Creutzfeldt–Jakob disease (CJD) compared to Alzheimerʹs disease (AD), we determined levels of tau phosphorylated at threonine 231 (p-tau231) and of total tau (t-tau) in cerebrospinal fluid (CSF) of CJD patients, AD patients, and healthy controls (HC). CJD patients showed excessively high t-tau levels but relatively low p-tau231 concentrations compared to the AD group. t-tau alone yielded the best diagnostic accuracy to differentiate between CJD and AD patients, when compared to p-tau231 and the p-tau231/t-tau ratio (97, 78, and 95% correctly allocated cases, respectively). Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD.
Keywords :
Alzheimer’s disease (AD) , diagnosis , Creutzfeldt–Jakob disease (CJD) , Cerebrospinal fluid (CSF) , Biological marker , Tauprotein , Phosphorylated tau protein , Differential diagnosis
