Author/Authors :
Sebastiaan Engelborghs، نويسنده , , Bart Dermaut، نويسنده , , Peter Marien، نويسنده , , Anoek Symons، نويسنده , , Ellen Vloeberghs، نويسنده , , Karen Maertens، نويسنده , , Nore Somers، نويسنده , , Johan Goeman، نويسنده , , Rosa Rademakers، نويسنده , , Marleen Van den Broeck، نويسنده , , Barbara Pickut، نويسنده , , Marc Cruts، نويسنده , , Christine Van Broeckhoven، نويسنده , , Peter P. De Deyn، نويسنده ,
Abstract :
To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimerʹs disease (AD) (N = 186), frontotemporal dementia (FTD) (N = 29), mixed dementia (MXD) (N = 28), dementia with Lewy bodies (DLB) (N = 11) and Parkinsonʹs disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimerʹs disease rating scale (Behave-AD)).
Keywords :
Psychosis , Behavior , Aggressiveness , Frontotemporal dementia , Delusions , BPSD , Hallucinations , Anxiety , ApoE , Alzheimer’s disease , dementia
