Title of article
Early impairment of synaptic plasticity in patients with Downʹs syndrome
Author/Authors
Fortunato Battaglia، نويسنده , , Angelo Quartarone، نويسنده , , Vincenzo Rizzo، نويسنده , , Maria Felice Ghilardi، نويسنده , , Alessandro Di Rocco، نويسنده , , Gaetano Tortorella، نويسنده , , Paolo Girlanda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1272
To page
1275
Abstract
We investigated synaptic plasticity in persons with Down’ syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.
Keywords
Transcranial magnetic stimulation , LTP , Down’s syndrome
Journal title
Neurobiology of Aging
Serial Year
2008
Journal title
Neurobiology of Aging
Record number
821234
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