PROTECTIVE ROLE OF MORINGA OLEIFERA ON NIMESULIDE INDUCED HEPATOTOXICITY IN ALBINO RAT MODEL

The objective of the present investigation was to study the protective role of aqueous extract of leaves of Moringa oleifera (MO) on nimesulide induced hepatotoxicity model in adult male albino rats. Hepatotoxicity in rats was caused by nimesulide at a dose of 10 mg /ml/kg body weight. Hepamerz, a drug used as standard hepatoprotective agent, was administered orally as standard hepatoprotective agent for 14 consecutive days prior to nimesulide treatment at a dose of 10mg/ml/kg body weight. This drug has many side effects. These side effects have prompted the scientific world for the search of alternative herbal based remedies of liver damage. The aqueous leaf extract of MO was administered orally to rats daily for 14 days before nimesulide treatment. The biochemical parameters were investigated. The results indicated that biochemical changes produced by nimesulide were restored to normal by aqueous extract of leaves of MO. The aqueous leaf extract of MO showed significant hepatoprotective effect through the modulation of antioxidant-mediated mechanism by altering serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), superoxide dismutase (SOD) and catalase (CAT) activities and reduced glutathione (GSH) and lipid peroxidation (LPO) levels against nimesulide induced hepatotoxicity model in rats. The present study puts future research agenda of whether to implement the results on albino rats upon hepatoprotectivity in human body.