Author/Authors :
Quintino Parisi، نويسنده , , Giuseppe G. L. Biondi-Zoccai، نويسنده , , Antonio Abbate، نويسنده , , Daniele Santini، نويسنده , , Fortunata Vasaturo، نويسنده , , Susanna Scarpa، نويسنده , , Rossana Bussani، نويسنده , , Antonio Maria Leone، نويسنده , , Alessandro Petrolini، نويسنده , , Furio Silvestri، نويسنده , , Luigi M. Biasucci، نويسنده , , Alfonso Baldi، نويسنده ,
Abstract :
We report hypoxia-inducible factor-1 (HIF-1) expression in myocardium of patients with recent acute myocardial infarction (AMI), supporting the hypothesis of HIF-1 as a possible mediator of response to ischemia. A potential diagnostic role of determining tissue expression of HIF-1 as a marker of ischemia, and potential therapeutic implications by trying to modulate HIF-1 activity in order to promote beneficial effects of HIF-1 related genes (e.g. expression of vascular endothelial growth factor (VEGF)) may derive.
