Author/Authors :
Wolfgang Linhart، نويسنده , , Wolfgang Lehmann، نويسنده , ,
Michael Siedler، نويسنده , , Fabian Peters، نويسنده , , Arndt F. Schilling، نويسنده , ,
Karsten Schwarz، نويسنده , , Michael Amling، نويسنده , ,
Johannes Maria Rueger، نويسنده , , Matthias Epple، نويسنده ,
Abstract :
Composites of amorphous carbonated apatite
and poly-(R)-3-hydroxybutyrate (PHB) and poly-(R)-3-hydroxybutyrate-
co-(R)-3-hydroxyvalerate (PHBHV), respectively,
were studied by pH monitoring upon immersion in
water and by long-term osteoblast culture. For comparison,
a-tricalcium phosphate (a-TCP), one glass ceramic (GB
9N), and one bioglass (Mg 5) were subjected to the same
experiments. Excellent cell proliferation was found on the
composite of calcium phosphate with PHB and on the reference
materials (a-TCP, glass ceramic, bioglass). In contrast,
cell death was observed repeatedly on the composite
with PHBHV. A composite of amorphous calcium phosphate
and PHB appears to be well suited as slowly biodegradable
bone substitution material.
