Author/Authors :
Eftekhar، Maryam نويسنده Department of Obstetrics and Gynecology, Yazd Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Rahsepar، Mozhgan نويسنده Yazd Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Rahmani، Elham نويسنده Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, Iran ,
Abstract :
Background: The transfer of cryopreserved embryos can be timed with ovulation in a natural cycle or after artificially preparing the endometrium with exogenous hormones. Progesterone is essential for the secretory transformation of the endometrium that permits
implantation
as
well
as
maintenance
of
early
pregnancy.
The
purpose
of
this
study
is
to assess the effect of luteal phase supplementation on pregnancy rates in natural frozen-thawed cycles.
Materials and Methods: The study was designed as a prospective randomized clinical trial of 102 women who underwent embryo transfers in natural cycles. The women in the interventional group (n=51) received intra muscular (IM) progesterone 50 mg twice a day starting from 36 hours after hCG administration. The control group (n=51) did not receive any progesterone support.
Results: There were no significant differences in demographic characteristics between the groups and no statistically significant differences were observed between study and control groups in clinical pregnancy rate (33.3% vs. 27.5%, p=0.66). There were no differences
in implantation rate or spontaneous abortion rate.
Conclusion: Our results suggest that luteal phase support does not affect clinical pregnancy
rates in natural frozen-thawed embryo transfer cycles (Registration Number: IRCT201108044339N6).
