Author/Authors :
ROGHAEI، MOHAMMAD ALI نويسنده , , Jamdar، Farzane نويسنده Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , , Ghaheri، Azadeh نويسنده Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, ,
Abstract :
Background: Immune-mediated recurrent pregnancy loss (RPL) has received more attention
than any other single etiologic classification. Individuals with rare blood group P have an antipp1pk
antibody in their serum, which causes recurrent abortion in the early stages.
Materials and Methods: In this case series study, 11 patients with unexplained RPL who
had anti-P antibody in their serum were treated by plasma exchange during their next
pregnancies. To evaluate the efficacy of the treatment, we monitored fetal development
using ultrasonography and intensive prenatal care. All calculations were performed with
the SPSS version 16.
Results: All patients who were treated by plasma exchange progressed to live birth. The
mean gestational age at the time of termination was 37.5 ± 0.69 weeks. The mean weight
of the newborns was 2729.09 ± 389.88 g. None of the newborns required exchange transfusion.
Conclusion: P-incompatibility is one rare but important cause of unexplained RPL and also a
basis for therapeutic intervention via early antibody removal by plasma exchange.
