Author/Authors :
Nasri، Hamid نويسنده , , Madihi، Yahya نويسنده Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan , , Merrikhi، Alireza نويسنده Assistant Professor, Department of Pediatric Nephrology, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan , , Gheissari، Allaleh نويسنده Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan , , Baradaran، Azar نويسنده Department of Pathology, Isfahan University of Medical Sciences, Isfahan , , Kheiri، Soleiman نويسنده .Department of Statistics, Medical Plants Research Center, Shahr-e-Kord University of Medical Sciences, Shahr-e-kord, Iran Kheiri, Soleiman , Rafieian-kopaei، Mahmoud نويسنده Department of Pharmacology, Medical Plants Research Center, Shahr-e-kord University of Medical Sciences, Shahr-e-Kord, Iran Rafieian-kopaei, Mahmoud
Abstract :
Background: Immunoglobulin A nephropathy (IgAN) with
nephrotic syndrome is an uncommon form of IgAN. Clinical and
morphological characteristics of proteinuria in IgAN, especially
when is in nephrotic range have not yet been fully examined.
This study was aimed to correlate morphologic variables of the
Oxford classification, and various clinical data with proteinuria
in IgAN patients. We also aimed to demonstrate the significance
of prevention of proteinuria as one of the important factors in
progression of this disease.
Methods: In an observational study conducted on IgAN patients,
total of 114 biopsies were entered in the study. IgAN was diagnosed
by light and immunofluorescence study.
Results: Of 114 patients 70.2% were male. Mean age of patients was
37.7 ± 13.6 years. The mean of proteinuria was 1742 ± 1324 mg/day.
Also mean of serum creatinine (Cr) was 1.6 ± 1.5 mg/dL. Of
114 patients, 11(9.6%) had nephrotic range proteinuria. In this
study, there was a positive correlation between proteinuria and
serum Cr, peri-glomerular fibrosis or interstitial fibrosis. There
was a positive association between proteinuria and totally sclerotic
glomeruli too. There was also a positive association between the
amount of fibrous crescents and the level of proteinuria. Nephrotic
proteinuria could just be seen in male patients. Also, nephrotic
syndrome had a positive association with the number of crescents.
Conclusions: Our findings firstly support the prognostic value of
crescent due to its association with proteinuria and secondly imply
the importance of treatment of proteinuria to prevent progression
of IgAN.
