A model of immune system with time-dependent immune reactivity Original Research Article

In this paper we deal with the Marchuk model of an immune system. Among the main parameters of the model are the coefficients which describe the state of infected organism and the rate of production of antibodies. In the classical model these coefficients are constants. We consider the case when these coefficients are time-dependent. In particular, we are interested in the case of periodic coefficients which can describe periodic changes of the immune reactivity due to periodic changes of the environment. We examine the asymptotic behaviour of solutions. Under some assumptions we prove that the solutions tend to periodic functions. We also present the results of numerical simulations to illustrate the behaviour of solutions.