Author/Authors :
Ataie ، Amin Amin نويسنده Cellular and Molecular Biology Research Center, Babol University of Medical Science, Babol, Iran. Ataie , Amin Amin , Ataee، Ramin Ramin نويسنده Pharmaceutical Sciences Research Center, Department of Pharmacology and Toxicology Mazandaran University of Medical Sciences, Sari, Iran. Ataee, Ramin Ramin , Mansoury، Zahra Zahra نويسنده Neuroscience research center. Shahid Beheshti University of Medical Sciences, Tehran, Iran Mansoury, Zahra Zahra , Aghajanpour Mir ، Seyed Mohsen نويسنده Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran ,
Abstract :
Parkinsonʹs disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinsonʹs disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in plasma have been associated with a number of disease states. Hcy (2 µmol / µl) was injected intracerebroventricular (i.c.v) in rats, five days later, the locomotor activity was measured with open field apparatus, Also apoptosis was investigated in substantia nigra cells by immunohistochemical analysis. Hcy could decrease locomotor activities significantly in rats as well as it could induce apoptosis in substantia nigra cells. These results suggest that Hcy is a neurotoxic metabolite and may induce cell death in some nuclei in the brain.
