• Title of article

    Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer

  • Author/Authors

    Shabanizadeh، Ahmad نويسنده Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , , Dahim، Hajar نويسنده Department of Pathology, Shahid Beheshti Hospital, Isfahan, Iran , , Salahshoor، Reza نويسنده Department of Anatomy, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran , , Taghipour، Zahra نويسنده Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , , Taghavi، Mohammad-Mohsen نويسنده Department of Anatomy, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Taghavi, Mohammad-Mohsen , Gafarineveh، Hamidreza نويسنده Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , , Eslami، Bahram نويسنده Department of Anatomy, Faculty of Nursing, Kashmar University of Medical Sciences, Kashmar, Iran , , Babazadeh، Zahra نويسنده Department of Anatomy, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , , Fatehi، Farangis نويسنده Department of physiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran ,

  • Issue Information
    فصلنامه با شماره پیاپی 13 سال 2013
  • Pages
    6
  • From page
    15
  • To page
    20
  • Abstract
    Background: Ovarian cancer is the leading cause of death among gynecological cancers. Changes in the methylation of BRCA1 and BRCA2 may be an effective mechanism for breast and ovarian cancer. This study evaluates the protein expression and methylation status of BRCA2 in Iranian patients. Methods: We assessed 60 Mullerian-type ovarian cancers by methylation-specific PCR assays and immunohistochemistry. Results: According to methylation status analysis, there were 7 of 60 (11.66%) methylated cases that had low protein expression. Conclusion: We concluded that changes in the methylation status of BRCA2 cannot be used as an appropriate biomarker to ascertain the development of ovarian cancer.
  • Journal title
    Middle East Journal of Cancer (MEJC)
  • Serial Year
    2013
  • Journal title
    Middle East Journal of Cancer (MEJC)
  • Record number

    889669

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=889669