Renal concentrating mechanism: Central core and vasa recta models Original Research Article

Mathematical models are essential in testing alternative hypotheses to explain the concentrating mechanism of the mammalian kidney. The basis features of a central core and two other vasa recta models, as well as efficient modeling techniques are described. It is shown that, by suitable choice of a few parameters, the two vasa recta models lead to the same osmolality and concentration ratios as the central core model.