Antimicrobial Potentials of Leptolyngbya sp. and Its Synergistic Effects With Antibiotics

Background: Resistance to antibiotics is a clinical problem. Cyanobacteria have many more antibiotic productions. Nowadays, combinations of antimicrobial compounds are used. Objectives: The current research studied antimicrobial properties of Leptolyngbya. Materials and Methods: Chloroform extracts of Leptolyngbya sp. were prepared. Antimicrobial effects of these extracts were evaluated singly and in combination with antibiotics against various microorganisms. Growth optimization, antimicrobial activity and their correlations were studied. Results: C. leptolyngbya had antimicrobial activity individually and in synergy with antibiotics against gram-positive and gram-negative bacteria. The highest activity of the chloroform extract was on gram positive strains and its effects on fungi were moderate, but it had a little effect against gram negative ones. Phosphate salt was the most important factor for growth and antibacterial activity in C. leptolyngbya. Conclusions: Optimization of medium composition and synergistic antimicrobial activity on the cyanobacteria could lead to production of effective antimicrobials.