Effect of Artemisia deserti flowering taps extract on liver in male rats

ABSTRACT: Liver transaminases: aspartate amino transferase (AST) and alanine amino transferase (ALT) are biomarkers of liver damage in a patient. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) are from the five significant groups of lipoproteins which allow lipids to be transported within the water-based blood flow. Multiple plants are used for the treatment of liver diseases. Therefore, the aim of this study is to evaluate the effects of extracts from Artemisia deserti extract on liver. Artemisia is a large, diverse genus of the family Asteraceae . In this study after collecting and provision plant, they were dried under shade and ground into fine powder using electric blender, then, 20 gr of flower powder were extracted with 150 mL 80% ethanol by Soxhlet extraction for 8 hours.The dried extracts were stored at 4°C until used. The animals were divided into three groups. Group 1 was injected with saline, group 2 and 3 were injected with extract 100 mg/kg and 200 mg/kg respectively. The animals were anesthetized and the AST, ALT, ALP, LDL and HDL were assayed. Also the liver tissue was separated and pathological changes were studied. No significant changes in liver enzymes were observed in all three groups. But, the flower extract of A. deserti cause changes in the liver tissue. The results are shown that the histopathological change probably due to the existing of artemisinin at extracts. It also seems liver disorders is resolved with time.