Author/Authors :
Mousavie Anijdan، Sayyed Hossein Sayyed Hossein نويسنده Department of Medical Physics, Babol University of Medical Sciences, Babol, Iran. Mousavie Anijdan, Sayyed Hossein Sayyed Hossein , Mahdavi، Seyyed Rabi Seyyed Rabi نويسنده Department of Medical Physics and Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mahdavi, Seyyed Rabi Seyyed Rabi , Shirazi، Alireza نويسنده , , Zarrinfard، Mohammad Ali Mohammad Ali نويسنده Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. Zarrinfard, Mohammad Ali Mohammad Ali , Hajati، Jamshid Jamshid نويسنده Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Hajati, Jamshid Jamshid
Abstract :
One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization performance with MV beams in-vivo, we used two most clinically used X-ray beams (6 and 18 MV) with the dose of 20 Gy for each mouse. Intratumoral injection of 50 nm GNPs with the concentration of 5 mg ml-1 was applied to melanoma tumor growing in the left leg of 7 to 8 mice in 4 control and treatment groups of C57BL/6 mice. Albeit, using 10 cm plexiglass jig phantom in the beam path improved the radiation - treatments, the statistical differences between groups were not significant. According to the results, it is concluded that mice can be treated with smaller tumors and higher concentrations of GNPs in MV radiation beams.
