Author/Authors :
Johnkennedy، Nnodim نويسنده Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri, Imo State, Nigeria , , Samuel، Meludu نويسنده Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State, Nigeria , , Uchegbu، Uche نويسنده Department of Microbiology Laboratory Services, Federal Medical Centre Owerri, Imo State, Nigeria ,
Abstract :
This study was done to determine and evaluate the level of lipid peroxidation product and vitamins C and E in rheumatoid arthritis. 150 rheumatoid arthritis and 150 healthy subjects between the ages of 45-60years attending General Hospital Owerri were selected in this study. Fasting veinous blood was collected and was used for the estimation of lipid peroxidation product and vitamins C and E in rheumatoid arthritis. The result obtained showed that the level of lipid peroxidation product was significantly increased in rheumatoid arthritis when compared with the healthy control (P < 0.05). On the other hand, the level of vitamins C and E were significantly reduced in rheumatoid arthritis when compared with the control (P < 0.05). This observation showed that rheumatoid arthritis is prone to oxidative stress and the antioxidant vitamins are excessively used to scavenge free radicals. Hence, the levels of antioxidant vitamins are depleted.
