Author/Authors :
Setorki، Mahbubeh نويسنده Department of Biology, Izeh Branch, Islamic Azad University, Izeh , , Rafieian-kopaei، Mahmoud نويسنده Department of Pharmacology, Medical Plants Research Center, Shahr-e-kord University of Medical Sciences, Shahr-e-Kord, Iran Rafieian-kopaei, Mahmoud , Merikhi، Alireza نويسنده , , Heidarian، Esfandiar نويسنده Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Sharekord , , Shahinfard، Najmeh نويسنده Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord , , Ansari، Roya نويسنده PHD Student of Animal Developmental Biology, Kharazmi University, Tehran, Iran Ansari, Roya , Nasri، Hamid نويسنده , , Esmael، Nafiseh نويسنده Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan , , Baradaran، Azar نويسنده Department of Pathology, Isfahan University of Medical Sciences, Isfahan ,
Abstract :
Background: We aimed to determine the effects of Anethum
graveolens (Dill) powder on postprandial lipid profile, markers of
oxidation and endothelial activation when added to a fatty meal.
Methods: In an experimental study, 32 rabbits were randomly
designated into four diet groups: normal diet, high cholesterol
diet (1%), high cholesterol diet plus 5% (w/w) dill powder
and high cholesterol diet plus lovastatin (10 mg/kg, bw). The
concentrations of glucose, total cholesterol (TC), low-density
lipoproteins-cholesterol (LDL-C), alanine aminotransferase (alt),
aspartate aminotransferase (ast), fibrinogen, factor VII,
apolipoprotein B (ApoB), nitrite and nitrate were measured in
blood samples following 15 h of fasting and 3 h after feeding.
Results: Concurrent use of A. graveolens powder or lovastatin
significantly decreased ALT, TC, glucose, fibrinogen and
LDL-C values in comparison with hypercholesterolemic diet
group (P < 0.05). Consumption of A. graveolens or lovastatin did
not change factor VII, ApoB, nitrite and nitrate levels significantly
in comparison with hypercholesterolemic diet group. Intake
of A. graveolens significantly decreased serum AST compared to
hypercholesterolemic diet.
Conclusions: A. graveolens might have some protective values
against atherosclerosis and that it significantly affects some
biochemical risk factors of this disease. Our findings also confirm
the potential harmful effects of oxidized fats and the importance
of dietary polyphenols in the meal.
