Association polymers for modulated release of bioactive proteins

The potential relevance for improving bone formation in and around tissueengineered constructs. The objectives of this study were to investigate erosion and release of biologically active protein from CAP/PF-127 blends in an environment more representative of local growth factor delivery into a low clearance site. Within this study, effects of polymer blend ratio, sampling interval, and multilayering were examined with the ultimate goal of obtaining multiphasic release profiles over a period of several days.