Evaluation of standardized ginseng extract Panax (G115 ®) effect on fasting blood glucose levels, glycated hemoglobin and lipid profile in patients with diabetes type 2

Abstract Introduction: Despite enormous efforts to search for cure, diabetes mellitus still remains as a formidable challenge for public health. This project was designed to evaluate effect of standardized ginseng extract Panaxs (G115®) on fasting blood glucose levels, glycated hemoglobin and lipid profiles in patients with diabetes type 2. Materials & Methods: In this randomized, double blind placebo controlled clinical trial, 30 patients with type 2 diabetes were contributed. They were divided into two groups (n=15 each), the randomized and placebo groups, the former received300 mg/day G115 and placebo received300 mg/d wheat flour. FBS, HbA1c and lipid profile were determined at baseline and at the end of study. SPSS version 18.0 (SPSS Inc, Chicago, IL, USA) was used for data analysis. Independent and paired samples T-test was applied for comparison. Results: Subjects randomized to G115, as compared to the placebo group, had a significant decrease in HbA1c (t= -2.593,p=0.015)) and FBS levels (t=-2.13,p=0.042). There was no improvement lipid profiles of subjects randomized to G115, compared to controls. Conclusion: Results of this study suggest that G115 supplementation in subjects with type 2 diabetes may improve glucose control but it has no significantly effect on lipid profiles. Keywords: Panax ginseng, Fasting blood glucose, Glycated hemoglobin, Lipid profiles