Effects of Interoceptive Stimulation on Glycemic Reactions in Brain Different Functional States under Physical Loading

As it issues from the conducted studies, in intact animals and in the animals of different ages kept in light regime after epiphys-ectomy glucose levels in the blood at 8.00-9.00 A.M. is minimal, in the afternoon, at 1.00-2.00 P.M. it up-regulates significantly, while in the evening, at 6.00-8.00 it gets down. In the animals kept under darkness regime the blood glucose levels run down. It is revealed that after subjecting to short-term physical loading in the 30, 90, 180-day-old animals in the morning, afternoon and evening time of circadian rhythm up-regulation of glycemic reactions is observed, whereas long-term physical loading results in down-regulation of this index values. After keeping the animals under 7-day light and darkness regimes and subjecting them to olfactoryectomy and interoceptive stimulation down regulation of the blood glucose level is observed, while after 14 days recovery in hypothalamo-hypophysal and other analysators systems takes place. On the grounds of the obtained data one can come to a conclusion that epiphysal hormone melatonin might be used for therapeutics purposes in the clinical practice.