Biochemical Alterations of Experimentally Induced Hypomagnesaemia in Male Baladi Goats

This study was performed to investigate the effect of experimental hypomagnesemia on glutathione redox cycle, nitric oxide, serum, glucose, calcium, inorganic phosphorus, magnesium, cortisone and insulin in baladi goats. Two groups of twelve healthy Baladi male goats were used; the first one contained 5 animals and kept as control group. The second group includes 7 animals administrated with potassium chloride and citric acid daily until the development of the characteristic signs of hypomagnesaemia observed. Blood samples were collected at 6, 12, 18 and 24 days of administration. The obtained results revealed that decreases in serum magnesium, calcium, inorganic phosphorus, insulin and nitrate concentration and erythrocytes glutathione peroxidase, reduced glutathione, glutathione reductase, glutathione-S-transferase and total superoxide dismutase activities were decreased whereas erythrocytes catalase activity, serum cortisone and glucose concentration were significantly increased in hypomagnesemic induced group when compared with the control group. From these results it could be conclude that nitric oxide release, glutathione redox cycle activities, insulin and cortisone levels were markedly affected by hypomagnesaemia. Such alterations may be considered as predisposing factors responsible for the tissue injury and vascular changes observed in hypomagnesaemia.