Author/Authors :
Banothu، Janardhan نويسنده Department of Chemistry, National Institute of Technology, Warangal, A.P., India , , Bavantula، Rajitha نويسنده Department of Chemistry, National Institute of Technology, Warangal, A.P., India , , Crooks، Peter A نويسنده Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA ,
Abstract :
A series of 2-amino pyridine-3-carbinitrile derivatives incorporated coumarin moiety has developed via multicomponent condensation of 3-acetyl-2H-chromen-2-one, arylaldehydes, malononitrile and ammonium acetate utilizing Br?nsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate as catalyst under solvent-free conditions. Good yields, short reaction times, straight forward workup, reusability of the ionic liquid and green conditions are the most obvious advantages of this methodology.
