• Title of article

    Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species

  • Author/Authors

    Pandurangan، Ashok Kumar نويسنده Department of Biochemistry, University of Madras, Chennai, Tamil Nadu, India , , Ganapasam، Sudhandiran نويسنده Department of Biochemistry, University of Madras, Chennai, Tamil Nadu, India ,

  • Issue Information
    فصلنامه با شماره پیاپی 16 سال 2013
  • Pages
    6
  • From page
    175
  • To page
    180
  • Arabic abstract
    Background: Colorectal cancer, a major health concern worldwide, is the third most common form of cancer and second leading cause of cancer-related deaths. The flavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods and important components of the human diet. Luteolin, a bioflavonoid, possesses many beneficial effects including antioxidant, anti-inflammatory, anti-allergic activities. Methods:We used the HCT-15 colon adenocarcinoma cell line in this study. Cells were treated with luteolin (100 µM). Results: Membrane damage markers such as alkaline phosphatase and lactate dehydrogenase were analyzed in a time-dependent manner. Luteolin increased reactive oxygen species in a time-dependent manner. DNA damage, a hallmark of apoptosis, was induced by luteolin as analyzed by agarose gel electrophoresis. Conclusion: Luteolin acts as a potential cytotoxic agent that can be used to treat colorectal cancer.
  • Journal title
    Middle East Journal of Cancer (MEJC)
  • Serial Year
    2013
  • Journal title
    Middle East Journal of Cancer (MEJC)
  • Record number

    945981

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=945981