Eclipsed exocyclic carbon-oxygen bonds in the hexamethyl ether of scyllo-inositol. X-ray crystallographic and NMR studies

Hexa-O-methyl-scyllo-inositol was synthesized and its crystal structure was determined by X-ray diffraction. As predicted by calculations, each oxygen-methyl bond eclipses the adjacent carbon-hydrogen bond. NMR studies show that the same conformation predominates in solution.