Synthesis of lactosyl phosphate diester derivatives of nucleosides

Derivatives of the lactosyl phosphate diester and the lactosyl thiophosphate diester of 1-(β-d-arabinofuranosyl)cytosine (Ara-C) and 9-(β-d-arabinofuranosyl)adenine (Ara-A) were synthesized by condensation of 3-hydroxypropyl lactoside and a protected Ara-C or Ara-A via H-phosphonate methodology and phosphoramidite methodology, respectively.