Title of article :
Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrane Original Research Article
Author/Authors :
Kiyoshi Ikeda، نويسنده , , Kimihiko Sano، نويسنده , , Masaki Ito، نويسنده , , Megumi Saito، نويسنده , , Kazuya Hidari، نويسنده , , Takashi Suzuki، نويسنده , , Yasuo Suzuki، نويسنده , , Kiyoshi Tanaka*، نويسنده ,
Abstract :
The synthesis of novel 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally varied at C-4 and C-9 by transformation from versatile key intermediates and their inhibitory activity against sialidase from influenza virus A and pig liver membrane are described.
Keywords :
Sialidase inhibitor , Cyanomethyl group , Influenza virus sialidase , Mammalian sialidase , Sialic acid
