Glycosylation of 2-thiohydantoin derivatives. Synthesis of some novel S-alkylated and S-glucosylated hydantoins

3-Aryl-5-((Z)-arylidene)-3-aryl-2-(2-methylthioethyl)-2-thiohydantoins 3a–f and 3-aryl-5-((Z)-arylidene)-2-(2′,3′,4′,6′-tetra-O-acetyl-β-d-glucopyranosyl)-2-thiohydantoins 7a–n were prepared from the reaction of 3-aryl-5-((Z)-arylidene)-2-thiohydantoins 2a–n with methylthioethyl chloride or 2′,3′,4′,6′-tetra-O-acetyl-α-d-glucopyranosyl bromide via three different routes. The compounds did not display any antiviral and antitumoral activity.