Title of article
Synthesis and evaluation of a C-glycosyl nucleoside as an inhibitor of chitin synthase Original Research Article
Author/Authors
Li Juan Xie، نويسنده , , Annie Thellend، نويسنده , , Hubert Becker، نويسنده , , Anne Vidal-Cros، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
6
From page
177
To page
182
Abstract
As part of our ongoing program devoted to inhibit chitin synthases, we have prepared a novel C-glycosyl nucleoside as metabolically stable substrate analog of UDP-GlcNAc. The synthetic strategy relies on the consecutive coupling of nucleoside and amino C-glycosyl moieties with l-tartaric acid. However, this compound inhibited only weakly chitin synthase I, with an IC50 value of 20 mM.
Keywords
Chitin synthase inhibitor , Substrate analog , C-Glycosyl nucleoside , Amino C-glycosyl compound
Journal title
Carbohydrate Research
Serial Year
2001
Journal title
Carbohydrate Research
Record number
963283
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