Title of article
Synthesis of 1,2,3-tri-O-acetyl-5-deoxy-d-ribofuranose from d-ribose Original Research Article
Author/Authors
Pothukuchi Sairam، نويسنده , , Ramachandra Puranik، نويسنده , , Bhatraju Sreenivasa Rao، نويسنده , , Ponnapalli Veerabhadra Swamy، نويسنده , , Sharad Chandra، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2003
Pages
4
From page
303
To page
306
Abstract
A practical route towards the synthesis of 1,2,3-tri-O-acetyl-5-deoxy-d-ribofuranose from d-ribose is described. The key steps include deoxygenation of methyl 2,3-O-isopropylidene-5-O-sulfonyloxy-β-d-ribofuranoside by reductive displacement employing hydride reagents. Subsequent total hydrolysis followed by acetylation led to the title compound in 56% overall yield from d-ribose. The sequence is simple, inexpensive, high yielding and clearly suitable for multi-gram preparations.
Keywords
Sodium bis-(methoxyethoxy) aluminium hydride (SMEAH) , Lithium tri-t-butoxyaluminum hydride (LTTBA) , 2 , 3-tri-O-acetyl-5-deoxy-d-ribofuranose , 1
Journal title
Carbohydrate Research
Serial Year
2003
Journal title
Carbohydrate Research
Record number
963644
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