Synthesis of new sugar amino acid derivatives of d-glucosamine Original Research Article

The synthesis of several new sugar amino acid derivatives of 2-acetamido-2-deoxy-d-glucose, bearing a C-glycosyl functionality as building blocks for the design and synthesis of natural glycoconjugates mimetics, is described. These compounds were prepared from the readily accessible per-benzylated amino C-allyl glucopyranosyl compounds, with TMSOTf/Ac2O-mediated selective acetolysis of the 6-O-benzyl group as the key step.